Differences in microRNA expression in pericoronary tissue adjacent to atherosclerotic plaque and from lesion-free coronary artery

Abstract Background Pericoronary adipose tissue (PCAT) plays a key role in the pathogenesis of atherosclerosis. PCAT is source microRNAs (miRs) that acts as messengers for intercellular communication. In this study, we investigated whether surrounding coronary occlusive atherosclerotic lesions shows specific miR expression patterns compared to plaque-free segments. Purpose To evaluate miRs are known be implicated pathophysiology Methods We included 49 patients (38 men, age 65±9 years) with 3-vessel artery disease, who underwent elective bypass surgery. The was harvested from two sites: adjacent an lesion, and segment. miR-133a, miR-21, miR-26b, miR-9 miR-143 levels cells were quantified by real-time reverse transcription polymerase chain reaction. Results miR-21 showed significantly greater samples taken around atheromatous plaque (154±295 versus 37±96, p=0.014, miR-26b; 122±265 29±79, miR-21; 181±356 31±50, p=0.03, miR-143) (Figure 1). addition, miR-143, miR-26b robust positive correlations body.mass index (r=0.451, p=0.001, r=0.41, p=0.03 r=0.416, p=0.003 respectively), Conclusions Analysis located proximity different pattern Our findings open new perspectives pathophysiological mechanisms disease should further investigated. Funding Acknowledgement Type funding sources: None.